GWAS

Gwas

That’s interesting. Care to elaborate? Part of the problem in trying to make a movie about real animals is that they aren’t actors. You can write a script — and there was one — but the chimps didn’t always follow it! So, like a good field worker, one had to adapt as the film footage came in and the story line changed. In this day and age of global warming, disease pandemics, and the like, it’s ...

Digesting GWAS

nce upon a time, medical genetics was a relaOtively straightforward business: one gene—one protein—one disease was sufficient to explain most inherited disease and was neatly in keeping with Gregor Mendel’s discovery of alleles with his famous peas. The concept remains a good starting point but the biology of life is somewhat more complex, and increasingly we have become impressed and perplexed...

GWAS in lung disease.

We read with interest the recent article ‘Genome-wide association studies in lung disease’ by Artigas et al. While we agree that a greater understanding of the biological pathways underlying disease development and progression (susceptibility) will be a major outcome from these genetic epidemiological studies, we suggest other benefits may also stem from this research. The genetics of chronic o...

Principles of GWAS

Select: GWAS Gets Functional

By identifying regions of the human genome linked to complex traits, genome-wide association studies (GWAS) are revolutionizing how researchers investigate common diseases, such as cancer and cardiovascular disease. However, as with many great scientific breakthroughs, skeptics have questioned the usefulness of this approach and whether GWAS can provide insights into the molecular mechanisms un...